6 edition of Membrane fusion in fertilization, cellular transport, and viral infection found in the catalog.
Includes bibliographies and index.
|Statement||guest editors, Nejat Düzgüneş, Felix Bronner.|
|Series||Current topics in membranes and transport ;, v. 32|
|Contributions||Düzgüneş, Nejat., Bronner, Felix.|
|LC Classifications||QH601 .C84 vol. 32|
|The Physical Object|
|Pagination||xvii, 384 p. :|
|Number of Pages||384|
|LC Control Number||88176106|
How viruses are transmitted across the mucosal epithelia of the respiratory, digestive, or excretory tracts, and how they spread from cell to cell and cause systemic infections, is incompletely understood. Recent advances from single virus tracking experiments have revealed conserved patterns of virus movements on the plasma membrane, including diffusive motions, drifting motions depending . Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the agents that fulfill this catalytic function. Despite a variety of molecular architectures, these proteins facilitate fusion by essentially the same generic mechanism.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function | Explore the latest full-text research PDFs. membrane fusion Sergio ovich and Yechiel Shai Infection by enveloped viruses requires fusion between the viral and cellular membranes,a process mediated by specific viral envelope glycoproteins. Information from studies with whole viruses,as well as protein dissection,has.
host cell. Secondly, they include a fusion protein function that can be activated to mediate fusion of viral and cellular mem-branes. Both tasks can be achieved by a single or by separate glycoproteins acting in concert. Depending on the viral family, fusion occurs either at the plasma membrane, where receptor binding triggers conforma-. Hemagglutinin is a class I viral fusion protein that catalyzes the membrane fusion process during cellular entry and infection. Impediment of the hemagglutinin’s function, either through incomplete post-translational processing (Klenk et al. ; Lazarowitz and Choppin ) or through mutations (Cross et al. ), leads to non-infective.
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Search in this book series. Membrane Fusion in Fertilization, Cellular Transport, and Viral Infection. Edited by Felix Bronner. Vol Pages ii-xviii, () Download full volume. Part I. Membrane Fusion in Fertilization and Development. select article Chapter 1 Sperm–Egg Fusion.
Jefferies, S. Khalid, in Modeling of Microscale Transport in Biological Processes, Membrane Fusion. Membrane fusion was one of the first applications of coarse-grain molecular modeling given its pertinence to fundamental processes in cell biology, such as viral infection, endocytosis and exocytosis, and fertilization.
From the outset, the coarse-grain simulation method. Membrane fusion in fertilization, cellular transport, and viral infection. San Diego: Academic Press, © (DLC) (OCoLC) Material Type: Document, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: Nejat Düzgüneş; Felix Bronner.
Membrane fusion is an important cell-physiological event that occurs in various intra-and intercellular processes, such as exocytosis, endocytosis, membrane genesis, viral infection, Membrane fusion in fertilization fertilization.
Hundreds of fusion events can occur every minute in a living cell. cell- cell fusion during fertilization A number of fundamental biological processes, ranging from fertilization and embryonic development to viral infections, depend upon a complex interplay between cells that results in the fusion of their plasma membranes.
Surprisingly, the cellular and. 1. Introduction. Membrane fusion is a key step in many biological processes. Processes such as intracellular compartmentalization and trafficking, neuronal signaling, entry of enveloped viruses, exocytosis, muscle repair, and cell-to-cell fusion in development all depend on enzymes that catalyze the merging of two lipid bilayers,.In cellular infection by enveloped viruses.
Rhabdoviruses enter the cell via the endocytic pathway and subsequently fuse with a cellular membrane within the acidic environment of the endosome. Both receptor recognition and membrane fusion are mediated by a single transmembrane viral glycoprotein (G). Fusion is triggered via a low-pH induced structural rearrangement.
Fertilization, union of a paternal sperm nucleus with a maternal egg nucleus to form the primary nucleus of an embryo. In higher organisms the essence of fertilization is the fusion of the hereditary material of two different sex cells.
Learn about the process of fertilization in this article. Enveloped viruses infect host cells by a membrane fusion reaction that takes place at the cell surface or in intracellular compartments following virus uptake.
Fusion is mediated by the membrane interactions and conformational changes of specialized virus envelope proteins termed membrane fusion proteins.
This article discusses the structures and refolding reactions of specific fusion proteins. During infection, the virus binds to a receptor on the host cell, and the viral and host-cell membranes fuse in order for the nucleocapsid to enter the cytoplasm Skehel and WileyLentz et al.
Viral fusion is carried out by single “universalist” proteins that mediate all steps of the fusion reaction, and that operate as “single.
Fusion of lipid vesicles and membranes is a fundamental intra- and inter-cellular transport mechanism, which lies at the heart of secretion, synaptic signal transmission, and viral infections. However, the cell membrane is by principle, a formidable barrier to fusion events and the ingenious biological systems designed by nature to enable cell.
Despite markedly different structures, both class I and class II viral membrane-fusion proteins adopt a hairpin conformation, inducing fusion of viral and cellular membranes.
This review focuses. Introduction. Entry of enveloped viruses into cells can be divided into three steps: (i) close apposition of viral and cellular membranes, (ii) lipid mixing of the outer membrane leaflets leading to formation of a hemifusion intermediate, and (iii) formation and expansion of a fusion pore allowing entry of the viral nucleoprotein or core into the cytoplasm.
membrane fusion inhibitors. Other Viral Membrane Fusion Reviews Clearly, there are many areas of study in the ﬁeld of viral membrane fusion. Al-though we try to at least touch on most subjects, many more thorough reviews on speciﬁc topics exist. Inﬂuenza HA has long been the paradigm for viral. Membrane fusion, one of the most fundamental processes in life, occurs when two separate lipid membranes merge into a single continuous bilayer.
Fusion reactions share common features, but are catalyzed by diverse proteins. These proteins mediate the initial recognition of the membranes that are destined for fusion and pull the membranes close together to destabilize the lipid/water interface.
This workshop will bring together scientists working in the membrane fusion events occurring in three broad categories: 1 - intracellular (fusion of vesicles, fusion of mitochondria, fusion of inner and outer nuclear membranes to make a fusion pore); 2 -extracellular fusion between cells; 3 - fusion of enveloped viruses with the membrane of.
Fertilization, fusion of mitochondria, and cell-cell fusion processes during development e ach us e dis tinct proteins for mem brane fusion[2,3,4]. One of the most easily studied. Chen and Olson have argued that, given current data, cell–cell fusion will prove to be substantially different from virus–cell or intracellular fusion.
In particular, cell–cell fusion will not use a mechanism based on fusion protein alpha‐helical bundles creating a hairpin‐like structure that brings the membranes into close proximity. Fusion is involved in many cellular processes, particularly in eukaryotes since the eukaryotic cell is extensively sub-divided by lipid bilayer membranes.
Exocytosis, fertilization of an egg by sperm and transport of waste products to the lysosome are a few of the many eukaryotic processes that rely on some form of fusion. Viral fusion also entails a hemifusion stalk (see Fig. 1 of ref. 8) and is accompanied by some lysis9, Though viral fusion proteins can be indiscriminate in their targeting, the similarity of their structures and actions to SNAREs (see Box 1 for definition) has been a powerful paradigm for studies of intracellular fusion Cell-cell fusion.
Fusion of HIV-1 with the membrane of its target cell, an obligate first step in virus infectivity, is mediated by binding of the viral envelope (Env) spike protein to its receptors, CD4 and CCR5.
Membrane fusion can occur between cells, between different intracellular compartments, between intracellular compartments and the plasma membrane and between lipid-bound structures such as viral.Fusion in Eukaryotes. Eukaryotic genomes contain several gene families, of host and viral origin, which encode products involved in driving membrane adult somatic cells do not typically undergo membrane fusion under normal conditions, gametes and embryonic cells follow developmental pathways to non-spontaneously drive membrane fusion, such as in placental formation.